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2018/5/8 10:13:14 | Browse: 754 | 下载: 784
Publication Name |
世界华人消化杂志 |
手稿编号 |
35792 |
手稿来源省、自治区或特别行政区 |
广东省 |
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Received |
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2018-03-11 08:06 |
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Peer-Review Started |
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2018-03-11 15:14 |
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To Make the First Decision |
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2018-03-22 08:16 |
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Return for Revision |
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2018-03-27 02:58 |
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修回稿 |
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2018-04-17 16:08 |
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Second Decision |
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2018-04-25 12:14 |
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期刊总编辑接受 |
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公司总编辑接受 |
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2018-04-26 15:08 |
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预出版 |
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2018-04-26 15:08 |
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缴纳版面费 |
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Edit the Manuscript by Language Editor |
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排版 |
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2018-05-05 07:16 |
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在线出版 |
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2018-05-08 09:11 |
ISSN |
1009-3079 (print) and 2219-2859 (online) |
开放获取 |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
版权 |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
网址 |
http://www.wjgnet.com |
专业类型 |
消化肿瘤学 |
手稿栏目类型 |
基础研究 |
文章标题 |
HBx蛋白及其羧基末端缺失35个氨基酸的突变体对正常肝细胞增殖的影响
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手稿来源 |
自由来稿 |
所有作者列表 |
朱冉旭, 羊东晔, 司徒伟基 |
基金项目及其编号 |
基金项目名称 |
基金编号 |
国家自然科学基金 |
81702777 |
广东省自然科学基金 |
2015A030310053 |
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通讯作者 |
朱冉旭, 博士, 主治医师, 518053, 广东省深圳市福田区海园一路(白石路与侨城东路交汇), 香港大学深圳医院消化内科. zhurx@hku-szh.org |
关键词 |
慢病毒载体; tHBxΔ35; HBx基因; 细胞增殖; 肝细胞; 凋亡 |
核心内容提要 |
乙型肝炎病毒(Hepatitis B Virus, HBV)编码HBx蛋白在原发性肝癌发展中发挥重要的作用. 在肝癌组织中, HBx 羧基末端频繁易丢失35个氨基酸, 形成自然突变体HBx (truncated HBx, tHBxΔ35); 本研究主要探讨HBx和tHBxΔ35对正常肝细胞增殖的影响. 结果发现HBx对肝细胞具有抑制增殖的作用, 而tHBxΔ35对肝细胞具有促进增殖的作用. |
出版日期 |
2018-05-08 09:11 |
引文著录 |
朱冉旭, 羊东晔, 司徒伟基. HBx蛋白及其羧基末端缺失35个氨基酸的突变体对正常肝细胞增殖的影响. 世界华人消化杂志 2018 |
URL |
http://www.wjgnet.com/1009-3079/full/v26/i13/760.htm |
DOI |
http://dx.doi.org/10.11569/wcjd.v26.i13.760 |
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