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2018/5/29 4:04:35 | Browse: 694 | 下载: 708
Publication Name |
世界华人消化杂志 |
手稿编号 |
35981 |
手稿来源省、自治区或特别行政区 |
山东省 |
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Received |
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2018-04-10 05:58 |
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2018-04-11 02:49 |
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To Make the First Decision |
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2018-04-23 06:24 |
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2018-04-24 01:50 |
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2018-05-11 12:44 |
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Second Decision |
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2018-05-16 10:57 |
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期刊总编辑接受 |
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公司总编辑接受 |
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2018-05-16 14:57 |
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预出版 |
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2018-05-16 14:57 |
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排版 |
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2018-05-23 01:09 |
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在线出版 |
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2018-05-28 06:50 |
ISSN |
1009-3079 (print) and 2219-2859 (online) |
开放获取 |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
版权 |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
网址 |
http://www.wjgnet.com |
专业类型 |
消化内科学 |
手稿栏目类型 |
述评 |
文章标题 |
反流高敏感
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手稿来源 |
约稿 |
所有作者列表 |
池肇春 |
基金项目及其编号 |
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通讯作者 |
池肇春, 本科, 教授, 主任医师, 266035, 山东省青岛市胶州路1号, 青岛市市立医院消化内科. c.z.chow@163.com |
关键词 |
功能性食管疾病; 烧心; 反流; 反流高敏感; pH-阻抗监测; 食管测压; 食管黏膜完整性; 神经调节剂 |
核心内容提要 |
反流高敏感(reflux hypersensitivity, RH)是新近提出的一种新的功能性疾病, 烧心时正常内镜出现在非糜烂性反流病(non-erosive reflux disease, NERD)和功能性烧心两种情况, NERD为异常酸暴露, 有阳性症状或阴性症状伴反流, 若正常酸暴露, 阴性症状伴反流称为功能性烧心, 若正常酸暴露, 阳性症状伴RH. 这是从RomeII、III逐步演变过来的概念. RH的提出显示人们对食管功能性疾病认识的进步与提高, 使诊断更为精准与合理. 随着人们对不同类型食管功能性疾病发病机制异同的了解, 提出了新的治疗策略, 如NERD是由异常酸暴露所致, 用质子泵抑制剂(proton pump inhibitor, PPI)治疗有反应; 而功能性烧心和RH则由正常酸暴露对酸敏感所致, 90%以上患者对PPI无反应, 因此, 目前治疗主要用食管神经调节剂, 然而疗效并不理想, 因此, 有望新的治疗策略问世. 新近研究证实食管对酸敏感和黏膜完整性破坏可导致RH发生. 今后需加强RH发病机制的研究, 以寻求更多新的且有高效的治疗方法, 拭目以待. |
出版日期 |
2018-05-28 06:50 |
引文著录 |
池肇春. 反流高敏感. 世界华人消化杂志 2018 |
URL |
http://www.wjgnet.com/1009-3079/full/v26/i15/885.htm |
DOI |
http://dx.doi.org/10.11569/wcjd.v26.i15.885 |
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