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2023/4/28 11:16:22 | Browse: 303 | 下载: 341
| Publication Name |
世界华人消化杂志 |
| 手稿编号 |
39188 |
| 手稿来源省、自治区或特别行政区 |
浙江省 |
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Received |
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2022-11-24 07:36 |
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2022-11-24 08:14 |
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2023-01-15 18:26 |
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2023-04-20 14:46 |
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2023-04-24 00:06 |
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2023-04-24 00:06 |
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缴纳版面费 |
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排版 |
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2023-04-28 03:31 |
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在线出版 |
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2023-04-28 11:04 |
| ISSN |
1009-3079 (print) and 2219-2859 (online) |
| 开放获取 |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| 版权 |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| 网址 |
http://www.wjgnet.com |
| 专业类型 |
消化肿瘤学 |
| 手稿栏目类型 |
基础研究 |
| 文章标题 |
长链非编码RNA PVT1诱导直肠癌细胞增殖、抑制凋亡并通过上调Atg5诱导其自噬
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| 手稿来源 |
自由来稿 |
| 所有作者列表 |
朱渊东, 刘海源, 雷鑫明, 彭雪强 |
| 基金项目及其编号 |
| 基金项目名称 |
基金编号 |
| 义乌市科研计划项目 |
20-3-165 |
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| 通讯作者 |
雷鑫明, 研究生, N/A, 324000, 浙江省衢州市闽江大道100号衢州市人民医院, 衢州市人民医院消化内科. 1542620591@qq.com |
| 关键词 |
直肠癌; LncRNA PVT1; 增殖和凋亡; 自噬; 自噬相关5同源物 |
| 核心内容提要 |
LncRNA PVT1基因作为lncRNAs的一种, 已经被证实在多种肿瘤中发挥促癌作用, 但对于该基因在直肠癌中的生物学行为报道较少, 因此, 本研究在结合国内外研究的基础上, 探讨lncRNA PVT1在直肠癌中表达以及与预后的关系, 以及对直肠癌自噬的调控机制和增殖凋亡的影响, 为直肠癌的靶向治疗提供可靠的靶点. 统计分析结果显示LncRNA PVT1在直肠癌组织和细胞中表达都显著增加. 并且lncRNA PVT1的表达直肠癌预后相关, 过表达lncRNA PVT1后激活直肠癌自噬和诱导肿瘤细胞增殖, 侵袭并且抑制其凋亡. |
| 出版日期 |
2023-04-28 11:04 |
| 引文著录 |
朱渊东, 刘海源, 雷鑫明, 彭雪强. 长链非编码RNA PVT1诱导直肠癌细胞增殖、抑制凋亡并通过上调Atg5诱导其自噬. 世界华人消化杂志 2023; 31(8): 307-315 |
| URL |
https://www.wjgnet.com/1009-3079/full/v31/i8/307.htm |
| DOI |
https://dx.doi.org/10.11569/wcjd.v31.i8.307 |
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