Publication Name	世界华人消化杂志
手稿编号	39555
手稿来源省、自治区或特别行政区	浙江省

Received	2023-07-08 23:50
Peer-Review Started	2023-07-08 23:56
To Make the First Decision
Return for Revision	2023-07-20 16:31
修回稿	2023-07-23 12:44
Second Decision	2023-08-04 02:45
期刊总编辑接受
公司总编辑接受	2023-08-04 03:33
预出版	2023-08-04 03:33
缴纳版面费
Edit the Manuscript by Language Editor
排版	2023-08-08 09:49
在线出版	2023-08-08 14:25

ISSN	1009-3079 (print) and 2219-2859 (online)
开放获取	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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专业类型	消化内科学
手稿栏目类型	临床实践
文章标题	卡瑞利珠单抗对晚期结直肠癌免疫功能及PD-1/PD-L1信号通路的近期疗效
手稿来源	自由来稿
所有作者列表	杜海旭, 洪春霞, 喻彤
基金项目及其编号
通讯作者	杜海旭, 本科, 主治医师, 321000, 浙江大学医学院附属金华医院药学部 浙江金华 321000, 浙江大学医学院附属金华医院药学部. fldfrf@163.com
关键词	结直肠癌; 卡瑞利珠单抗; 程序性细胞死亡蛋白1; 程序性死亡配体1; 免疫功能; 疗效; 安全性
核心内容提要	本文探究奥沙利铂、卡培他滨联合卡瑞利珠单抗对晚期结直肠癌患者疾病进展的影响. 研究结果发现, 联合卡瑞利珠单抗可改善晚期结直肠癌患者营养状态, 提升身体体能, 其作用机制可能是通过介导程序性细胞死亡蛋白1(programmed cell death protein 1, PD-1)/程序性死亡配体1(programmed death ligand 1, PD-L1)信号通路, 进而调节PD-1、PD-L1表达水平, 发挥改善免疫、抑制癌细胞增殖的作用.
出版日期	2023-08-08 14:25
引文著录	杜海旭, 洪春霞, 喻彤. 卡瑞利珠单抗对晚期结直肠癌免疫功能及PD-1/PD-L1信号通路的近期疗效. 世界华人消化杂志 2023; 31(15): 647-654
URL	https://www.wjgnet.com/1009-3079/full/v31/i15/647.htm
DOI	https://dx.doi.org/10.11569/wcjd.v31.i15.647

Full Article (PDF)	WCJD-31-647-with-cover.pdf
补充材料	WCJD-39555-Informed consent statement.pdf
审稿意见	WCJD-39555-Peer-review(s).pdf
科学编辑工作清单	WCJD-39555-Scientific editor work list.pdf