Publication Name	世界华人消化杂志
手稿编号	39569
手稿来源省、自治区或特别行政区	浙江省

Received	2023-07-22 09:09
Peer-Review Started	2023-07-22 09:19
To Make the First Decision
Return for Revision	2023-09-02 18:38
修回稿	2023-09-08 01:53
Second Decision	2023-09-26 13:26
期刊总编辑接受
公司总编辑接受	2023-09-26 20:04
预出版	2023-09-26 20:04
缴纳版面费
Edit the Manuscript by Language Editor
排版	2023-10-27 08:44
在线出版	2023-10-28 02:28

ISSN	1009-3079 (print) and 2219-2859 (online)
开放获取	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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专业类型	消化内科学
手稿栏目类型	临床实践
文章标题	解整合素-金属蛋白酶33基因多态性与胆管癌及血清肿瘤标志物水平的相关性研究
手稿来源	自由来稿
所有作者列表	邱雷, 危贵君
基金项目及其编号
通讯作者	邱雷, 本科, 主任药师, 主治医师, 313000, 湖州市吴兴区广场后路158号湖州市第一人民医院2号楼消化内科, 湖州市第一人民医院消化内科. azrsml0451@163.com
关键词	胆管癌; 解整合素-金属蛋白酶33; 单核苷酸多态性; 易感性
核心内容提要	目前认为胆管癌(cholangiocarcinoma, CC)的发病与肝炎、糖尿病、吸烟、饮酒、基因多态性、肥胖等多种因素有关. 研究发现, 胆管癌组织中(disintegrin and metalloproteinase, ADAM)33蛋白表达显著升高, 且与预后不良有关. ADAM33 rs678881 GC、CC基因型及C等位基因增加胆管癌的易感性及血清肿瘤标志物的水平, 可能参与了CC的病理进程.
出版日期	2023-10-28 02:28
引文著录	邱雷, 危贵君. 解整合素-金属蛋白酶33基因多态性与胆管癌及血清肿瘤标志物水平的相关性研究. 世界华人消化杂志 2023; 31(20): 871-876
URL	https://www.wjgnet.com/1009-3079/full/v31/i20/871.htm
DOI	https://dx.doi.org/10.11569/wcjd.v31.i20.871

Full Article (PDF)	WCJD-31-871-with-cover.pdf
补充材料	WCJD-39569-Informed consent statement.pdf
审稿意见	WCJD-39569-Peer-review(s).pdf
科学编辑工作清单	WCJD-39569-Scientific editor work list.pdf