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2019/7/8 8:50:41 | Browse: 720 | 下载: 769
| Publication Name |
世界华人消化杂志 |
| 手稿编号 |
36855 |
| 手稿来源省、自治区或特别行政区 |
海南省 |
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Received |
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2019-03-20 03:22 |
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Peer-Review Started |
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2019-03-22 00:18 |
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To Make the First Decision |
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2019-04-04 01:10 |
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Return for Revision |
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2019-04-10 02:40 |
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修回稿 |
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2019-06-09 11:13 |
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Second Decision |
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2019-06-19 07:40 |
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期刊总编辑接受 |
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公司总编辑接受 |
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2019-06-25 00:45 |
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预出版 |
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2019-06-25 00:45 |
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缴纳版面费 |
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Edit the Manuscript by Language Editor |
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排版 |
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2019-07-05 09:00 |
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在线出版 |
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2019-07-08 08:50 |
| ISSN |
1009-3079 (print) and 2219-2859 (online) |
| 开放获取 |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| 版权 |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| 网址 |
http://www.wjgnet.com |
| 专业类型 |
消化内科学 |
| 手稿栏目类型 |
基础研究 |
| 文章标题 |
表达持续活化型ALK3抑制大鼠肝星状细胞活化
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| 手稿来源 |
自由来稿 |
| 所有作者列表 |
石慧, 柳长柏, 肖和杰 |
| ORCID |
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| 基金项目及其编号 |
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| 通讯作者 |
柳长柏, 博士, 高级研究员, 教授, 443000, 大学路8号, 三峡大学肿瘤微环境与免疫治疗湖北省重点实验室. 295489660@qq.com |
| 关键词 |
骨成形蛋白7; Smadl; 磷酸化Smadl; 肝星状细胞 |
| 核心内容提要 |
利用BMP-7Ⅰ型受体的持续性活化突变基因真核表达载体, 建立稳定高表达持续活化型BMP-7Ⅰ型受体ALK3细胞株.无需BMP-7刺激, 持续活化型ALK3即可激活下游信号通路, 证实BMP-7信号转导通过增强Samd1的磷酸化而拮抗TGF-β1致纤维化作用, 抑制大鼠肝星状细胞的活化, 从而逆转肝纤维化,解决临床上肝硬化难以逆转的问题, 挽救早期肝硬化患者. |
| 出版日期 |
2019-07-08 08:50 |
| 引文著录 |
石慧, 柳长柏, 肖和杰. 表达持续活化型ALK3抑制大鼠肝星状细胞活化. 世界华人消化杂志 2019 |
| URL |
https://www.wjgnet.com/1009-3079/full/v27/i13/807.htm |
| DOI |
https://dx.doi.org/10.11569/wcjd.v27.i13.807 |
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